β-Bisabolene is a sesquiterpene isolated from opoponax (Commiphora guidotti). β-Bisabolene, an anti-cancer agent, can be used for the study of breast cancer.

Product information

CAS Number: 495-61-4

Molecular Weight: 204.35

Formula: C15H24

Chemical Name: (4S)-1-methyl-4-(6-methylhepta-1,5-dien-2-yl)cyclohex-1-ene

Smiles: CC(C)=CCCC(=C)[C@@H]1CC=C(C)CC1

InChiKey: XZRVRYFILCSYSP-OAHLLOKOSA-N

InChi: InChI=1S/C15H24/c1-12(2)6-5-7-14(4)15-10-8-13(3)9-11-15/h6,8,15H,4-5,7,9-11H2,1-3H3/t15-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

β‐bisabolene exhibits selective cytotoxic activity for mouse cells, it against normal Eph4, MG1361 and 4T1 cells with IC50 values of >200 µg/ml, 65.49 µg/ml, and 48.99 µg/ml, respectively. It against normal MCF‐10A, MCF‐7, MDA‐MB‐231, SKBR3 and BT474 cells with IC50 values of 114.3 µg/ml, 66.91 µg/ml, 98.39 µg/ml, 70.62 µg/ml and 74.3 µg/ml, respectively.

In Vivo:

β‐bisabolene is effective in reducing the growth of transplanted 4T1 mammary tumours in vivo (37.5% reduction in volume by endpoint).

References:

1. Syn Kok Yeo,et al. β-Bisabolene, a Sesquiterpene From the Essential Oil Extract of Opoponax (Commiphora Guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines. Phytother Res. 2016 Mar;30(3):418-25.

Products are for research use only. Not for human use.